Ang My Husband's Lover ay pinangungunahan nina Carla Abellana (Lally), ang bagong Kapusong si Tom Rodriguez (Vincent) and Dennis Trillo (Eric). Kasama rin nila sina Roi Vinzon, Kuh Ledesma, Karel Marquez, Bettina Carlos, Victor Basa, Kevin Santos and Miss Glydel Mercado. The show's headwriter is the brilliant GMA writer Miss Suzette Doctolero (Encantadia, Amaya, One True Love) and director is Dominic Zapata (TGIS 2nd Gen, Mulawin, Diva, Luna Blanca, Temptation of Wife).
Ang kuwento ng My Husband's Lover ay umiikot sa mag-asawang si Lally at Vincent. Napaaga ang pagpapakasal nila dahil sa hindi inaasahang pagbubuntis ni Lally na ikinagalit ng ina nito. Naging okay ang pagsasama nilang mag-asawa despite sa laging pangingialam ng mother-in-law ni Lally sa kanila. But unknown to Lally, may hindi pa pala siya nalalaman sa kanyang asawa, that her husband is a closet gay. And that Vincent had a past relationship with his High School Bestfriend, si Eric. It was shown in the flashbacks that Eric and Vincent had a colorful and a happy relationship, until Eric needs to go out of the country dahil na-comatose ang daddy niya. At doon nakilala ni Vincent si Lally. And now, Eric is back at nagulat siya na may asawa na si Vincent.
