She's The One is about bestfriends Cat (Alonzo) and Wacky (Dantes). Despite their chemistry and despite a kiss that happened one night, never na naging sila and they remained bestfriends. But they have hidden feelings for each other...well except for Cat na alam nang buong barkada niya. One night, in a middle of a typhoon, nasiraan si Cat ng kotse, and a guy named David (Gil) saw her and immediately caught his attention, kaya naman vinideohan niya ito and he posted sa Internet with the hashtag #girlintherain. At dahil pabagsak na ang ratings ng morning show ni Wacks, he helped David about this Girl in the Rain. Later on, malalaman na si Cat pala ito. Fast forward to everything, magiging si David and Cat, and Wacky will get jealous.
